Research & Developments
Installation of SPNPSE-1 Near-Field Electrospinning
We are pleased to announce the successful installation and commissioning of the SPNPSE-1 near-field electrospinning system. This state-of-the-art capability expands our micro/nano-fabrication infrastructure, empowering high-precision fiber alignment and micro-patterning for next-generation neural tissue regeneration and specialized biomaterial scaffolds.
Direct-Write Precision
Facilitates ordered, micron- and sub-micron fiber deposition with high spatial accuracy for directed axonal guidance and customized 3D microarchitectures.
Neural Scaffold Architecture
Seamlessly integrates with our bio-ink formulations and hybrid fabrication workflows to engineer physiologically biomimetic constructs for CNS and PNS research.
SPNPSE-1 / SUPER NFES-1 System
High-Precision Near-Field Electrospinning Facility
Check out our published works!
3D-Neural Tissue Culture
3D-Bioprinting & Scaffolding
Neuroscience
Scientific Publications
- Agrawal, Lokesh, Menouer Saidani, Laurent Guillaud, and Marco Terenzio. 2021. “Development of 3D Culture Scaffolds for Directional Neuronal Growth Using 2-Photon Lithography.” Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems 131 (December): 112502–2. https://doi.org/10.1016/j.msec.2021.112502.
- Agrawal, Lokesh, Sunil Kumar Vimal, Paolo Barzaghi, Takashi Shiga, and Marco Terenzio. 2022. “Biodegradable and Electrically Conductive Melanin-Poly (3-Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications.” Macromolecular Bioscience, September, 2200315. https://doi.org/10.1002/mabi.202200315.
- Pathak, Nishit, Sunil Kumar Vimal, Ishi Tandon, Lokesh Agrawal, Cao Hongyi, and Sanjib Bhattacharyya. 2022. “Neurodegenerative Disorders of Alzheimer, Parkinsonism, Amyotrophic Lateral Sclerosis and Multiple Sclerosis: An Early Diagnostic Approach for Precision Treatment.” Metabolic Brain Disease 37 (1): 67–104. https://doi.org/10.1007/s11011-021-08000-w.
- Sunil Kumar Vimal, Hongyi Cao, Amit Dubey, Lokesh Agrawal, Nishit Pathak, Hua Zuo, Deepak Kumar, and Sanjib Bhattacharyya. 2022. “In Vivoandin Silicoinvestigations of the Pegylated Gold Nanoparticle Treatment of Amyotrophic Lateral Sclerosis in Mice.” New Journal of Chemistry 46 (25): 12252–64. https://doi.org/10.1039/d2nj00452f.
- Agrawal, Lokesh, Mustafa Korkutata, Sunil Kumar Vimal, Manoj Kumar Yadav, Sanjib Bhattacharyya, and Takashi Shiga. 2020. “Therapeutic Potential of Serotonin 4 Receptor for Chronic Depression and Its Associated Comorbidity in the Gut.” Neuropharmacology 166: 107969. https://doi.org/10.1016/j.neuropharm.2020.107969.
- Maria Fransiska Emily, Lokesh Agrawal, P. Barzaghi, Miki Otsuki, and Marco Terenzio. 2022. “Use of Microfluidics Chambers to Image Axonal Transport in Adult Sensory Neurons.” Methods in Molecular Biology, January, 271–88. https://doi.org/10.1007/978-1-0716-1990-2_14.
Ongoing Developments
AI for Research & Healthcare
Bioinformatics & Machine Learning
Regenrative Medicine & Implants
We are pioneering the use of biomaterials, stem cells, and blood-derived proteins to develop novel regenerative therapies for conditions affecting blood, skin, muscle, bone, and neural tissues. Our approach has the potential to expand into immunotherapy for patients in critical need. In parallel, we are leveraging the power of artificial intelligence and machine learning to enhance the precision and efficiency of our bioprinting and electrospinning systems. Through advanced algorithms and predictive modeling, we aim to enable personalized treatment strategies that ensure targeted and effective interventions. By integrating AI/ML with our next-generation bioprinting technologies and biomaterials, we are driving a new era of precision healthcare—committed to transforming the future of medicine and biomedical research.
Our Collaborators
